Michael Levin: Anatomical decision-making by cellular collectives

Thomas Ouldridge · 31K views · 2021 · 1:18:06

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Biology & biotechnologyEvolution & geneticslecture

Why Hacker News recommends it

HN commenters push it as an example of Levin's talks, which they think deserve far more attention.

What it is

Michael Levin presents his lab's work on how cellular collectives use bioelectric networks to make anatomical decisions. Topics include pattern memories, regeneration and synthetic living organisms.

Recommended by 3 HN commenters across 3 different months, 2021 to 2023.

What Hacker News said

Strong rec dosman33 · 2021-07 · on “Mike Levin on using bioelectricity to study how cells form (2019)”

Moar people need to be talking about this guys work, a buddy clued me in to it last year. Creating new species without any genetic changes... it's huge. Not only has he discovered a new communication control channel in biology, machine learning is unlocking the commands to intelligently manipulate that channel at will. It's many times deeper this too, this is incredible work. Want those tree-grown steaks rather than a stew of muscle cells with no structure? This work is how you grow an intact cow muscle without the rest of the cow with ease. Want to tell those cancer cells using your body as a petrie dish to knock it off and to start working with the rest of your body again? This is a direct

Recommends carapace · 2021-10 · on “On The Origin Of Minds”

In re: Michael Levin, do see his talks "What Bodies Think About: Bioelectric Computation Outside the Nervous System" [LINK] and "Anatomical decision-making by cellular collectives" [this video]

Recommends Spakman · 2022-08 · on “Ask HN: What's the next big thing that few people are talking about?”

I'm not nearly educated enough about this subject to try to summarise it, but the research being carried out by Michael Levin's group into how organisms control anatomy growth is completely fascinating and has the feel of a breakthrough. Almost all the talks I've seen are good, for example: [this video] Creating new species without genetic changes seems wild!

Cites ly3xqhl8g9 · 2023-01 · on “Major standard library changes in Go 1.20”

Oh, but the "organic" solutions do highly deterministic, extremely programmable computational work: 99.99999+% of newborns have 2 hands, 2 legs, and 1 head, and they all started development from a single cell [1]. It's just that the "organic" solutions are written in a 4+ billion year-old highly redundant, distributed, resilient, evolved language whereas our CPUs are not on the same phylogenetic tree. The quotation marks around organic are just there to point out that there is something wrong with the dichotomy organic (various pro/eu-karyotes from bacteria to humans)/inorganic (from thermostats to CPUs). [1] Michael Levin: Anatomical decision-making by cellular collectives [this video]

Cites koliber · 2023-05 · on “New Nightmare, the Hammerhead Worm”

I don't know about this particular species, but some planaria can be split into more than one piece and regenerate. A record is over 60 from what I recall from this video: [this video]